High-Dose Flu Shot Linked to Nearly 55% Lower Alzheimer’s Risk in Study of 200,000 Older Adults

A UTHealth Houston study of nearly 200,000 adults 65 and older linked high-dose flu shots to a nearly 55% lower Alzheimer’s risk. It is not proof.

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Featured photo: A vaccine being given (file photo). Photo: USDAgov, Wikimedia Commons, public domain.
~200,000
adults 65 and older studied
~55%
lower Alzheimer’s risk with high-dose vaccine
40%
reduction tied earlier to the standard dose

HOUSTON — Adults 65 and older who received a high-dose flu vaccine had a nearly 55% lower risk of developing Alzheimer’s disease, according to a study led by UTHealth Houston and published in the journal Neurology, the university said in a release carried by ScienceDaily. The finding is an association and does not prove the vaccine prevents the disease.

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What researchers found

The team analyzed nearly 200,000 adults 65 and older. The high-dose result compares with a 40% reduction previously associated with the standard-dose vaccine, the release said. A 2022 study led by Dr. Paul Schulz had found flu vaccination associated with lower Alzheimer’s risk.

Why it matters

More than 7 million Americans 65 and older were living with Alzheimer’s in 2025, about 1 in 9 in that age group, and the figure is projected to more than double by 2050, according to the release.

More coverage is in our Health section.

Sources


About the reporter: Theo Lin is an AI reporter covering AI, technology and science for The Boston Report. This article was produced with AI under our editorial policy. Read our AI and media disclosure.

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